Aortic and Cerebral Aneurysms: Link With Genetic Predisposition, Risk Factors, and Aortopathies

Aortic and Cerebral Aneurysms

  • Kristina Selthofer-Relatic* Department of Internal Medicine, General Medicine and History of Medicine, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Croatia; Department of Cardiovascular Diseases, University Hospital Centre Osijek, Croatia
  • Luka Švitek Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Croatia
  • Nora Pušeljić Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Croatia
  • Željka Breškić Ćurić Department of Internal Medicine, General Hospital Vinkovci, Croatia

Abstract

Abstract

 Routine cardiology practice includes diagnostic algorithms for thoracic aortic aneurysm detection at varying degrees of clinical significance. Standard procedures for evaluation and follow up involve screening for standard atherosclerotic risk factors, including hypertension, dyslipidemia, diabetes mellitus, obesity, smoking history and family history without genetic testing, as well as cardiac imaging techniques, such as echocardiography, computed tomography or magnetic resonance imaging. According to the latest reports, thoracic aortic aneurysms can present concomitantly with intracranial aneurysms, although the exact etiopathogenic mechanisms are not yet known. There is evidence that connects these two conditions with genetic predisposition, risk factors, and aortopathies. Routine practice does not include screening for other aneurysm locations. This review will highlight existing knowledge in this area and the need for further investigations.


(Švitek L, Pušeljić N, Breškić Ćurić Ž, Selthofer-Relatić K. Aortic and Cerebral Aneurysms: Link with Genetic Predisposition, Risk Factors, and Aortopathies. SEEMEDJ 2019; 3(1); 29-41)


KEYWORDS: atherosclerosis, aortic aneurysm, genetics, inflammation, intracranial aneurysm

Published
Jun 4, 2019
How to Cite
SELTHOFER-RELATIC*, Kristina et al. Aortic and Cerebral Aneurysms: Link With Genetic Predisposition, Risk Factors, and Aortopathies. Southeastern European Medical Journal, [S.l.], v. 3, n. 1, p. 29-41, june 2019. ISSN 2459-9484. Available at: <http://seemedj.mefos.unios.hr/index.php/seemedj/article/view/91>. Date accessed: 25 june 2019.
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Articles