A Cross-Talk between Renin-Angiotensin and Adrenergic System in Cardiovascular Health and Disease

  • Ana Stupin* Department of Physiology and Immunology, Faculty of Medicine Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
  • Ines Drenjancevic Department of Physiology and Immunology, Faculty of Medicine Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
  • Lidija Rasic Department of Physiology and Immunology, Faculty of Medicine Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
  • Anita Cosic Department of Physiology and Immunology, Faculty of Medicine Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
  • Marko Stupin Department for Cardiovascular Diseases, Osijek University Hospital, Osijek, Croatia

Abstract

It is well accepted that a number of cardiovascular (CV) and renal diseases are characterized by long-term activation of both renin-angiotensin system (RAS) and sympathetic nervous system (SNS) which also contribute to the pathophysiology of structural and functional CV abnormalities as well as to final clinical outcome. Moreover, there is a growing body of conclusive evidence that these systems do not operate independently, but interact at different levels throughout the CV system. Mediation of renin release from juxtaglomerular epithelioid (JGE) cells in kidney by SNS is well established and accepted. On the other hand, in recent years it became evident that RAS, by its main effector angiotensin II (Ang II), induces SNS activity in various organs and tissues. Thus, there is a growing effort to clarify pathophysiological mechanisms of interaction and more evident mutual potentiation of these two systems in different pathological states. Since it become evident that a high salt (HS) intake, which is a major risk factor for hypertension development, has a deleterious impact on vascular and endothelial function (even in the absence of blood pressure changes) it became necessary to investigate and clarify the effect of HS loading on major regulating systems, RAS and SNS precisely in healthy individuals. The present review aimed to summarize the interactions between the RAS and SNS in health and diseases (e.g. cardiovascular, renal), with special focus on these two systems interaction during HS intake in healthy normotensive population.

Published
May 9, 2017
How to Cite
STUPIN*, Ana et al. A Cross-Talk between Renin-Angiotensin and Adrenergic System in Cardiovascular Health and Disease. Southeastern European Medical Journal, [S.l.], v. 1, n. 1, p. 90-107, may 2017. ISSN 2459-9484. Available at: <http://seemedj.mefos.unios.hr/index.php/seemedj/article/view/33>. Date accessed: 23 sep. 2017.