Etiology of developmental delay in the pediatric population

  • Višnja Tomac* Clinical Hospital Centre Osijek, Department of Pediatrics
  • Silvija Pušeljić Department of Pediatrics, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
  • Ivana Škrlec Department of Medical Biology and Genetics, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
  • Mirna Anđelić Department of Medical Biology and Genetics, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
  • Martina Kos Pediatric Clinic, Clinical Hospital Centre Osijek, Osijek, Croatia
  • Jasenka Wagner Department of Medical Biology and Genetics, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia

Abstract

Intellectual disability/mental retardation (ID/MR) is defined as incomplete mental and cognitive development present from childhood. There are number of pre-natal and post-natal risk factors that can cause ID/MR, but about 50% of all causes are genetic. ID/MR has prevalence of about 2% in the general population. Using standard cytogenetic methods analysis of chromosomes (GTG banding) and molecular genetic analysis for fragile X chromosome reveals only a small number of causes, but the use of new molecular genetic techniques  has increased the rate of detection of subtle chromosomal aberrations, as well as the discovery of new candidate genes in etiology of ID/MR. These methods will improve the diagnosis and treatment of patients, as well as genetic counseling of parents.

Published
Jun 2, 2017
How to Cite
TOMAC*, Višnja et al. Etiology of developmental delay in the pediatric population. Southeastern European Medical Journal, [S.l.], v. 1, n. 1, p. 144-153, june 2017. ISSN 2459-9484. Available at: <http://seemedj.mefos.unios.hr/index.php/seemedj/article/view/28>. Date accessed: 20 sep. 2017.