Cytomegalovirus Infection in Kidney Transplant Recipients

  • Dino Šisl* University of Zagreb School of Medicine, Department of Physiology and Immunology, Croatian Institute for Brain Research, Laboratory for Molecular Immunology
  • Lada Zibar Department for Nephrology, Internal Clinic University Hospital Merkur, Zagreb; Department for Pathophysiology, Faculty of Medicine, University Josip Juraj Strossmayer Osijek, Croatia

Abstract

Introduction: Present study examined the frequency of CMV infection during follow-up using quantitative nucleic acid amplification testing, the frequency of administration of infection prophylaxis, viremia and infection in kidney transplant recipients who underwent transplantation (TX) at the University Hospital Center Osijek.


Materials and Methods: 107 kidney recipients who underwent transplantation in the period 20 October 2007 – 24 August 2016 were included. Demographic and clinical data, data about pre-transplantation CMV IgG test results of recipients and their donors, data about CMV prophylaxis, viremia, infection, and kidney transplant function were taken from medical records and analyzed.


Results: 92.5% of kidney recipients and 86% of donors were CMV IgG positive before TX. 28% of recipients were CMV-DNA positive at some point after TX, none of whom received a transplant from an IgG negative donor. 89.7% of participants received CMV prophylaxis. Seven participants developed CMV disease, 2 of whom were not administered prophylaxis. Participants were tested for CMV-DNA once a year (median; min 0 max 6). CMV disease was marginally more frequent in those who did not receive valganciclovir prophylaxis (P = 0.066).


Conclusion: It seems wise to enforce the administration of CMV prophylaxis and CMV-DNA testing in accordance with protocol, in order to detect viremia on time and to implement preemptive treatment, aiming at prevention of clinical manifestation of infection and preservation of graft function.

Published
Apr 28, 2021
How to Cite
ŠISL*, Dino; ZIBAR, Lada. Cytomegalovirus Infection in Kidney Transplant Recipients. Southeastern European Medical Journal, [S.l.], v. 5, n. 1, p. 17-24, apr. 2021. ISSN 2459-9484. Available at: <http://seemedj.mefos.unios.hr/index.php/seemedj/article/view/203>. Date accessed: 18 oct. 2021. doi: http://dx.doi.org/10.26332/seemedj.v5i1.203.
Section
Articles