Survival in Dialysis or Plasma Exchange Treated Patients for Multiple Myeloma – A Single Centre 25 Year Experience

  • Petra Smajić* Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Croatia
  • Ema Schönberger Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Croatia
  • Vlatka Periša Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Croatia; Clinical Hospital Centre Osijek, Croatia
  • Jasminka Sinčić Petričević Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Croatia; Clinical Hospital Centre Osijek, Croatia
  • Lada Zibar Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Croatia; University Hospital Merkur, Zagreb, Croatia
  • Kristina Kralik Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Croatia

Abstract

Aim: Multiple myeloma (MM) patients might require haemodialysis (HD) and/or plasma exchange (PE) in cases of acute kidney injury (AKI) and/or chronic kidney disease (CKD) and/or other indications. The study analysed the survival of MM patients who required HD and/or PE.


Subjects and methods: All 144 patients treated for MM at the University Hospital Centre Osijek between 1994 and 2018 (of whom 47.9 % were men) were included in the study. Data were collected from medical records. MedCalc Statistical Software version 17.8.2 was used for the statistical analysis, with significance set at α = 0.05.


Results: Forty-three of 144 MM patients (29.9 %) were treated with HD and/or PE. Male patients required HD or PE more often than female patients (62.8 % vs 37.2 %, P = 0.02). Patients who did not require HD or PE were significantly older at the time of their death than the patients treated with HD or PE [75 (interquartile range, IQR, 72 – 77) vs 72 (IQR 66 – 75) years; P = 0.009, Mann-Whitney test]. Among all patients who required acute or chronic HD, PE or a combination of the treatments, the longest life span was found in 17 patients who were treated with chronic HD (median 12 months, IQR 8 – 58).


Conclusion: Kidney failure requiring HD or PE in MM was associated with a significantly shorter life span in comparison with other MM patients. Chronic HD patients had the longest survival among patients who required acute or chronic HD, PE or a combination of the treatments. In general, MM patients in need for HD and/or PE had poor survival.


(Smajić* P, Schönberger E, Periša V, Sinčić Petričević J, Zibar L, Kralik K. Survival of Multiple Myeloma Patients Undergoing Dialysis or Plasma Exchange - A Single Centre’s 25-Year Experience. SEEMEDJ 2020; 4(1); 25-31)

Published
Apr 24, 2020
How to Cite
SMAJIĆ*, Petra et al. Survival in Dialysis or Plasma Exchange Treated Patients for Multiple Myeloma – A Single Centre 25 Year Experience. Southeastern European Medical Journal, [S.l.], v. 4, n. 1, p. 26-32, apr. 2020. ISSN 2459-9484. Available at: <http://seemedj.mefos.unios.hr/index.php/seemedj/article/view/126>. Date accessed: 07 july 2020. doi: http://dx.doi.org/10.26332/seemedj.v4i1.126.
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Articles